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 | | THE PERCEIVED AND PHYSIOLOGICAL EFFECTS OF PEA PROTEIN ISOLATE (PISANE®) ON SATIETY | | | Cosucra | | 09/06/2008 | | | Pea protein isolate (Pisane®) promotes biomarkers for satiety, such as delayed gastric emptying, higher PYY levels and lower ghrelin levels.
The control of food intake, associated with weight management, is one of the main health concerns at the moment. Recent scientific data have demonstrated that satiety is associated with the release of gastro-intestinal peptides that stimulate the central nervous sytem in order to initiate or to stop a meal (Wynne et al., 2005; Cummings & Overduin, 2007).
Cosucra Groupe Warcoing has recently participated in a collaborative research project with Leatherhead Food International on the perceived and physiological effects of dietary proteins and peptides on satiety.
Some widely used biomarkers of hunger and satiety were measured to assess the effects of pea protein isolate, Pisane®, on satiety. These were PYY, ghrelin and gastric emptying as measured by paracetamol release into the blood.
11 healthy volunteers (age: 38 ± 2.3 years, mean BMI: 23 ± 0.5) have participated to the study. They were requested to consume a standardized breakfast followed 2h30 later by a high protein preload (48 g of protein from pea) or a control preload without protein. A standardized lunch was served 2h30 after the consumption of the preload.
Blood samples were taken at regular intervals from the preload intake and validated VAS (visual analogue scale) questionnaires were completed at regular intervals from the breakfast. Absolute and delta values, i.e. change from baseline for the different parameters measured revealed differences between pea protein isolate and the control.
The analysis of some time points revealed that ghrelin levels were statistically lower than the ones of the control with Pisane® after the consumption of the standardised lunch. As ghrelin is stimulates feeding, lower levels could indicate a delay in the return of appetite after a meal and hence increase satiety.
Higher PYY levels are associated with a delayed gastric emptying, and therefore an increased satiety. Levels of PYY were significantly higher for the Pisane® preload than for the control at two time-points.
Gastric emptying was also significantly slower with Pisane® versus the control (see figure 1). A reduced rate of gastric emptying is associated with a better satiety since the volume of food consumed has a greater effect on a meal size than its energy content.
Regarding Visual Analogue Scales (VAS), delta value analysis of the results for “How hungry do you feel?” “How full do you feel?” indicate positive effects on satiety and fullness for Pisane® compared with the control. This study demonstrates that Pisane® has a greater effect on satiety than the control (higher PYY and lower ghrelin levels from several time-points and slower gastric emptying). Analysis of delta values revealed that Pisane® has the greatest effect on satiety, which last throughout the day, suggesting that once a difference in satiety is gained it remains unaltered. Cathy Signoret, Nutritional & Regulatory Manager, Cosucra Groupe Warcoing | |
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