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 | | NEW SCIENTIFIC EVIDENCE OF SVETOL’S UNIQUE MECHANISM OF ACTION | | | Berkem | | 08/02/2008 | | | For the first time, the green coffee extract Svetol has been demonstrated to inhibit the glucose-6-phosphatase explaining its fat burning action.
A recent study carried out by Bordeaux University (Polyphenol Biotech), permitted to elucidate Svetol’s unique mechanism of action. According to this study, Svetol inhibits the glucose-6-phosphatase (Glc-6-Pase).
“We demonstrated for the first time that Svetol, a unique green coffee bean extract, is able to inhibit the Glc-6-Pase in a significant and competitive manner,” explained Sophie Lafay, Ph.D. in Nutrition and Scientific Director at Berkem. “The in vitro active doses are equivalent to the daily recommended dose of Svetol,” she added.
Numerous epidemiological studies reported a link between a high consumption of coffee (more than 6-7 cups/day) and a reduced risk of developing type 2 diabetes. In vitro and in vivo complementary tests suggested that chlorogenic acids (CGA) – especially 5-caffeoylquinic acid mainly found in green coffee beans – could regulate glucose metabolism. In fact, in vitro studies have shown that pure 5-caffeoylquinic acid inhibits glucose-6-phosphatase (Glc-6-Pase), hepatic enzyme involved in the glucose release from the liver in blood circulation.
However, the mechanism of action of a total extract of green coffee beans has never been studied. The analytical characterisation of Svetol permitted to identify more than 12 different chlorogenic acids – including 5-caffeoylquinic acid – in specific ratios. These results bring to light Svetol’s uniqueness compared to other green coffee extracts.
That’s the reason why Berkem decided to validate Svetol’s activity on Glc-6-Pase. Three concentrations have been tested, equivalent to 157 mg, 315 mg and 472 mg of Svetol per liter of solution. After incubation of human liver microsomes with or without Svetol, we observed that Svetol is able to inhibit competitively the Glc-6-Pase, especially its T1 unit, at 315 mg/L and 472 mg/L.
These results are really promising in terms of innovation. Berkem established, for the first time, that Svetol– a complex ingredient extracted from selected green coffee beans – is able to inhibit the T1 unit of the Glc-6-Pase in human microsomes. These results are primarily linked to the fat burning action of Svetol demonstrated in a previous clinical study (published work). Indeed, a daily 400 mg supplementation with Svetol induces a significant reduction in the body mass index (BMI) as well as a significant 4% increase of the lean mass to fat mass ratio.
Successfully launched in Europe, Svetol is an original active ingredient for weight management. Svetol is perfectly suited to dietary supplements, and could also achieve high success in a variety of foods, as well as beverages. Its unique and identified mechanism of action permits to combine Svetol easily with other weight management ingredients for a synergic result. | |
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